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Gut microbiota health linked to bacterial infections

A section of mouse gut colonised by Citrobacter bacteria (white patches) after 4 days of infection. Copyright: Eve Hopkins and Gad Frankel / Imperial College London
News from: University of Glasgow

The health and balance of the gut microbiota is important in the progression of a bacterial infection, according to new research, supported by BBSRC.

A new study, led by the University of Glasgow and published in Nature Communications, found that disease-causing bacteria were taking signals from the host’s gut microbiota in order to spread and progress the infection.

Using Citrobacter, a bacterium that infects mice and is a model for the human pathogen, E. coli, researchers were able to see that the bacteria were using signals produced from the microbiota to trigger the disease process and develop a prolonged infection.

This is the first time scientists have been able to understand the process of Citrobacter infection inside a host, rather than in laboratory settings, allowing a much greater understanding of the key role played by the gut’s microbiota in the process.

The researchers found that the bacteria used certain chemicals produced from the microbiota in order to enhance the infection and cause more severe disease.

The researchers believe their work demonstrates the importance of healthy gut nutrition and the microbiota has on the susceptibility to and the progression of bacterial infections such as E. coli.

Professor Andrew Roe, lead author of the study, said: “Our work focuses on understanding exactly how bacteria cause disease within animals. Through Citrobacter we have been able to show the key role played by the microbiota and how bacteria such as E. coli might use host signals to spread and increase infection.”

The paper, ‘Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion’ is published in Nature Communications. The work was done in collaboration with Imperial College London and as funded by BBSRC and the Wellcome Trust.


Tags: news University of Glasgow microbes human health health